HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → HCID 19807720, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-5-(3-chloro-4,5,6,7-tetrahydroindazol-2-yl)-4-fluorophenol | HCID 185078 | — |
| Reactant | 3-(Chloromethyl)-5,6-dihydro-2H-pyran | HCID 19807722 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 19807720 | HCID 19807720 | 84% |
Reaction Steps
2.1 g (16 mmol) of 3-chloromethyl-5,6dihydro-2H-pyran were added at 25° C. to a mixture of 4.5 g (15 mmol) of 3-chloro-2-(4-chloro-2fluoro-5-hydroxyphenyl)-4,5,6,7-tetrahydroindazole, 2.5 g (18 mmol) of potassium carbonate and 0.5 g (3 mmol) of sodium iodide in 50 ml of dimethylformamide, and the reaction mixture was stirred for 12 hours. 100 ml of water were added, and the precipitate was isolated, washed with water and dried, resulting in 5 g (84%) of the title compound [melting point 90° to 92° C⟧ Compound No. 1.002.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04997472 |
| Source dataset | uspto-grants-1991_03 |
| ORD ID | ord-bcaf5008ba814466baaf4592109dfdb0 |
| Source note | uspto-grants-1991_03 |