反应详情

208 mg of 1,1-diethyl-3-[13-(1-hydroxy-1-methyl-ethyl)-2,6- -dimethyl-8alpha-ergolinyl]-urea (0.5 mmol) is dissolved in 20 ml of anhydrous tetrahydrofuran, mixed with 0.7 ml of triethylamine (5 mmol) and 0.4 ml of methanesulfonic acid chloride (5 mmol) and stirred for 30 minutes at room temperature. Ice is added to the mixture, it is made alkaline with conc. ammonia and shaken out with ethyl acetate. The residue is chromatographed on silica gel with dichloromethane/methanol, yield 99 mg (50% of theory).

1. additionIce is added to the mixture, it
2. customThe residue is chromatographed on silica gel with dichloromethane/methanol, yield 99 mg (50% of theory)