Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Butenoic acid, 3-amino-, ethyl ester → Ethyl 2-methyl-4-phenyl-1,4-dihydropyridine-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Butenoic acid, 3-amino-, ethyl ester | HCID 95308 | — |
| 반응물 | Cinnamaldehyde | HCID 637511 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Piperidine | HCID 8082 | — |
| 생성물 | Ethyl 2-methyl-4-phenyl-1,4-dihydropyridine-3-carboxylate | HCID 14652661 | 72.3% |
반응 단계
(E)-3-Phenyl-2-propenal (13.8 ml, 0.11 mol) and ethyl 3-amino-2-butenoate (12.9 g, 0.1 mol) were dissolved in 150 ml of absolute ethanol containing 0.5 ml of piperidine. The mixture was heated under reflux for 18 hours followed by removal of the solvent under vacuum to yield 17.6 g of ethyl 1,4-dihydro-2-methyl-4-phenyl-3-pyridinecarboxylate as a brown viscous oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04997837 |
| 출처 데이터셋 | uspto-grants-1991_03 |
| ORD ID | ord-42e9defa45784b289909b967b73d63bc |
| 출처 메모 | uspto-grants-1991_03 |