反应详情

Freshly distilled 1-Benzyl-4-piperidone (11.7 g) was added to a stirred solution of 5-bromoindole (11.0 g) in 2M potassium hydroxide in methanol (81ml). The mixture was stirred at reflux for 8 h and then allowed to cool to 25° over 8 h. The solid was collected by filtration, washed with a mixture of methanol:water (2:1, 2×15 ml) and dried in vacuo at 50° for 18 h to give the title compound as a crystalline solid (18.6 g) m.p. 173°-175° (decomp).

1. temperatureat reflux for 8 h
2. temperatureto cool to 25° over 8 h
3. filtrationThe solid was collected by filtration
4. washwashed with a mixture of methanol:water (2:1, 2×15 ml)
5. customdried in vacuo at 50° for 18 h