Sodium Hydroxide → HCID 20066954, compound

Participants

Reaction Steps

A solution of ethyl 8-(4-chlorobenzenesulphonamido)-2,2-dimethyloctanoate (1.0 g), sodium hydroxide (1.5 g) in ethanol (40 ml) and water (5 ml) was stirred at room temperature for 90 hours then refluxed for 3 hours. The solvent was removed and the residue was dissolved in dilute hydrochloric acid, the resulting solution then being extracted with chloroform (3×50 ml). The combined chloroform extracts were dried over magnesium sulphate, the solvent was removed and the residue was recrystallised from isopropanol-water to give the title compound as a white solid (0.7 g) m.p. 95°-96° C.

Provenance & Evidence