反应详情

4-Chlorobenzenesulphonyl chloride (0.31 g) in chloroform (2 ml) was added to a rapidly stirred solution of 7-aminohept-5-ynoic acid (0.2 g) and sodium hydroxide (0.21 g) in water (3 ml) and stirring was continued for 24 hours. The solution was extracted with chloroform (4×10 ml). The remaining aqueous layer was cooled, treated with hydrochloric acid and the resulting precipitate was collected by filtration and recrystallised from isopropanol-water to give the title compound (0.085 g). m.p. 91°-93° C.

1. extractionThe solution was extracted with chloroform (4×10 ml)
2. temperatureThe remaining aqueous layer was cooled
3. additiontreated with hydrochloric acid
4. filtrationthe resulting precipitate was collected by filtration
5. customrecrystallised from isopropanol-water