Sodium Hydroxide → HCID 20066960, compound

HRID 358645Notes

Reaction equation

HRID 358645 reaction equation
[CH3:1][C:2]([CH3:21])([CH2:9][CH2:10][NH:11][S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:14])=[O:13])[CH2:3][C:4]([O:6]CC)=[O:5].[OH-].[Na+]>CO>[CH3:1][C:2]([CH3:21])([CH2:9][CH2:10][NH:11][S:12]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)(=[O:14])=[O:13])[CH2:3][C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20066952Ethyl 3,3-dimethyl-5-[(phenylsulfonyl)amino]pentanoate

Product 1

HCID 20066960HCID 20066960, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of ethyl 3,3-dimethyl-5-(benzenesulphonamido)pentanoate (4.4 g, 14.1 mmol), methanol (30 ml) and 2N NaOH (20 ml) was stirred for 5 hours at 60° C. The methanol was then evaporated, the aqueous phase was acidified (diluted HCl) and the oily acid was extracted with methylene chloride. After drying over sodium sulphate the solvent was removed. Yield: 4.0 g (100 % of theory), oily product, nD20 =1.5250.

Workup

  1. customThe methanol was then evaporated
  2. extractionthe oily acid was extracted with methylene chloride
  3. dry with materialAfter drying over sodium sulphate the solvent
  4. customwas removed

Sources & evidence

ORD record
ord-d879bf0fb4c040a2bcab8dcb4ab98c0c
Source dataset
uspto-grants-1991_03
Patent number
US04997847

Reaction notes

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