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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 358648Generated: October 26, 2026

Ethyl isobutyrate → Ethyl 7-bromo-2,2-dimethylheptanoate

https://huagongshe.com/reaction/358648

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl isobutyrateHCID 7342—
Reactant1,5-DibromopentaneHCID 8100—
ReactantLithium diisopropylamideHCID 2724682—
SolventHexamethylphosphoramideHCID 12679—
ProductEthyl 7-bromo-2,2-dimethylheptanoateHCID 1126557131%

Reaction Steps

Using the method described in Example 5(i). 1,5-dibromopentane (23 g, 0.1 mol) and ethylisobutyrate (10.4 g, 0.09 mol) were reacted in the presence of lithium diisopropylamide (0.1 mol) and hexamethylphosphoramide (22 g) to give the title compound as an oil (7.4 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04997847
Source datasetuspto-grants-1991_03
ORD IDord-c6a0f4ab1c4d43bc9b410e9eae49386a
Source noteuspto-grants-1991_03