HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (2S)-1-benzoylpyrrolidin-2-al
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Pyrrolidinemethanol, 1-benzoyl-, (2S)- | HCID 12830794 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2S)-1-benzoylpyrrolidin-2-al | HCID 14824832 | — |
Reaction Steps
A solution of (2S)-1-benzoylpyrrolidine-2-methanol (24.1 g) in methylene chloride (120 ml) was added dropiwise to the solution at -70° C. The mixture was stirred for 30 mins. Triethylamine (89.5 ml) was added dropwise to the reaction solution at -70° C. The mixture was stirred for 50 mins at the same temperature, and then rised to 0° C. gradually. Water was added to the solution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05411974 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-597cf2d7184f46d1bcc60501c1dfd96d |
| Source note | uspto-grants-1995_05 |