Water → N-[2-(Chloroacetyl)phenyl]-N-methylformamide

HRID 358660Notes

Reaction equation

HRID 358660 reaction equation
S(Cl)([Cl:4])(=O)=O.[C:6]([C:9]1[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=1[N:11]([CH3:14])[CH:12]=[O:13])(=[O:8])[CH3:7].O>ClCCl>[Cl:4][CH2:7][C:6]([C:9]1[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=1[N:11]([CH3:14])[CH:12]=[O:13])=[O:8]

Participants

5

Reactant 3

HCID 962WaterHCID 24648Sulfuryl chlorideHCID 12261279Formamide, N-(2-acetylphenyl)-N-methyl-

Product 1

HCID 23128087N-[2-(Chloroacetyl)phenyl]-N-methylformamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of sulphuryl chloride (119 ml) in dichloromethane (168 ml) was added dropwise to the o solution of 2'-acetyl-N-methylformanilide at 0° under a nitrogen atmosphere. The mixture was stirred for 2 hours at 0° and then cold (5°) water (488 ml) was added dropwise over a period of 1 hour. The dichloromethane layer was separated and dried over magnesium sulphate to give a solution of 2'-(2-chloroacetyl)-N-methylformanilide.

Workup

  1. customThe dichloromethane layer was separated
  2. dry with materialdried over magnesium sulphate

Sources & evidence

ORD record
ord-2e7a509f758444b99286737fb6e91ccd
Source dataset
uspto-grants-1991_03
Patent number
US04997840

Reaction notes

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