2,2,2-Trifluoroethanol → HCID 23128080, compound

Participants

Reaction Steps

2,2,2-Trifluoroethanol (7.0 ml) was added to a stirred suspension of sodium hydride (4.0 g of a 50% dispersion in mineral oil) in dioxan (60 ml). After 30 minutes 3-allyloxy-7-fluoro-1-methyl-4-quinolone (2.8 g) was added and the mixture heated under reflux for 24 hours. The solvent was removed by evaporation under reduced pressure at 40°. The residue was dissolved in water (150 ml) and the solution extracted with dichloromethane (3×150 ml). The combined extracts were dried over magnesium sulphate and evaporated to give the novel compound 3-allyloxy-1-methyl-7-(2,2,2-trifluoroethoxy)-4-quinolone, m.p. 120°.

Provenance & Evidence