Sodium Hydroxide → HCID 23128127, compound

Participants

Reaction Steps

A mixture of 3-hydroxy-1-methyl-7-(2,2,2-trifluoroethoxy)-4-quinolone (0.40 g), aqueous sodium hydroxide (5M, 0.43 ml) and water (10 ml) was stirred under nitrogen at 0°. Methanesulphonyl chloride (0.25 g) was added with stirring and the pH adjusted to 9 with aqueous sodium hydroxide (5M, 0.5 ml). The resultant solid was collected by filtration, washed with water (10 ml) and crystallised from industrial methylated spirit (10 ml) to give the novel compound 1-methyl-4-oxo-7-(2,2,2-trifluoroethoxy)-1,4-dihydro-quinol-3-yl methanesulphonate, m.p. 110°-112°.

Provenance & Evidence