Water → HCID 23128117, compound

HRID 358688Notes

Reaction equation

HRID 358688 reaction equation
S(Cl)([Cl:4])(=O)=O.[C:6]([C:9]1[CH:19]=[CH:18][CH:17]=[CH:16][C:10]=1[N:11]([CH2:14][CH3:15])[CH:12]=[O:13])(=[O:8])[CH3:7].O>ClCCl>[Cl:4][CH2:7][C:6]([C:9]1[CH:19]=[CH:18][CH:17]=[CH:16][C:10]=1[N:11]([CH2:14][CH3:15])[CH:12]=[O:13])=[O:8]

Participants

5

Reactant 3

HCID 962WaterHCID 24648Sulfuryl chlorideHCID 23128148HCID 23128148, compound

Product 1

HCID 23128117HCID 23128117, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of sulphuryl chloride (12.7 ml) in dichloromethane (20 ml) was added dropwise to the solution of 2'-acetyl-N-ethylformanilide at 0° and the mixture stirred at 0° for 4 hours. Water (110 ml) was then added whilst maintaining the temperature below 10°. The dichloromethane layer was separated, washed with water (110 ml) and aqueous sodium chloride (6M, 250 ml) and then dried over magnesium sulphate to give a solution of 2'-(2-chloroacetyl)-N-ethylformanilide.

Workup

  1. temperaturewhilst maintaining the temperature below 10°
  2. customThe dichloromethane layer was separated
  3. washwashed with water (110 ml) and aqueous sodium chloride (6M, 250 ml)
  4. dry with materialdried over magnesium sulphate

Sources & evidence

ORD record
ord-8626b069cb004011bcb69502da9e4edc
Source dataset
uspto-grants-1991_03
Patent number
US04997840

Reaction notes

Loading…