Dimethyl Sulfoxide → HCID 15660982, compound

Participants

Reaction Steps

A mixture of (2RS)-2-[(2S)-1-[3-(N-benzyl-N-methlcarbamoyl) propanoyl]pyrrolidin-2-yl]-2-hydroxyacetic acid (134 mg), potassium carbonate (64 mg), benzyl bromide (51 μl) and DMSO (1 ml) was stirred for 1 hr at room temperature. Water was added to the mixture. The mixture was extracted with a mixture of hexane and EtOAc (1:1). The extract was washed, dried and evaporated. The residue was purified by column chromatography on silica gel (hexane-EtOAc) to give the title compound (141 mg) having the following physical data:

Provenance & Evidence