Water → HCID 23128168, compound

Participants

Reaction Steps

Methanesulphonyl chloride (0.88 ml) was added to a stirred suspension of 3-hydroxy-7-methoxy-1-methyl-4quinolone (0.7 g) and triethylamine (2.4 ml) in dry dichloromethane (100 ml) at ambient temperature and the resultant solution stirred for 3 hours. Water (50 ml) was added and the layers separated. The dichloromethane layer was dried over magnesium sulphate and the solvent evaporated. The residue was purified by flash chromatography on a silica gel column eluted with dichloromethane:methanol (19:1) followed by crystallisation from acetonitrile:methanol (20:1, 10 ml) to give the novel compound 7-methoxy-1-methyl-4-oxo-1,4-dihydroquinol-3-yl methanesulphonate, m.p. 163°.

Provenance & Evidence