Water → HCID 23128088, compound

HRID 358705Notes

Reaction equation

HRID 358705 reaction equation
S(Cl)([Cl:4])(=O)=O.[C:6]([C:9]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:10]=1[N:11]([CH3:14])[CH:12]=[O:13])(=[O:8])[CH3:7].O>ClCCl>[Cl:19][C:16]1[CH:17]=[CH:18][C:9]([C:6](=[O:8])[CH2:7][Cl:4])=[C:10]([CH:15]=1)[N:11]([CH3:14])[CH:12]=[O:13]

Participants

5

Reactant 3

HCID 962WaterHCID 24648Sulfuryl chlorideHCID 23128111HCID 23128111, compound

Product 1

HCID 23128088HCID 23128088, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of sulphuryl chloride (9 ml) in dichloromethane (15 ml) was added dropwise to the solution of 2'-acetyl-5'-chloro-N-methylformanilide under nitrogen whilst maintaining the temperature at 0 to Water (40 ml) was then added dropwise whilst maintaining the temperature at 0 to 10°. The mixture was stirred for a further 5 minutes and then the dichloromethane layer was separated and dried over magnesium sulphate to give a solution of 5'-chloro-2'-(2-chloroacetyl)-N-methylformanilide.

Workup

  1. additionwas then added dropwise
  2. temperaturewhilst maintaining the temperature at 0 to 10°
  3. customthe dichloromethane layer was separated
  4. dry with materialdried over magnesium sulphate

Sources & evidence

ORD record
ord-10693eb569aa4c4a88eaea968e70c429
Source dataset
uspto-grants-1991_03
Patent number
US04997840

Reaction notes

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