Bromine → HCID 23128171, compound

Participants

Reaction Steps

Bromine (1.57 ml) was added dropwise over a period of 5 minutes to a stirred solution of 2'-acetyl-4',5'-dimethoxy-N-methylformanilide (7.13 g) in glacial acetic acid (35 ml) at ambient temperature. The mixture was stirred for 45 minutes and then diluted with dichloromethane (350 ml) before washing with saturated aqueous sodium sulphite (175 ml) then aqueous sodium bicarbonate (1M, 350 ml). The mixture was dried over magnesium sulphate and the solvent was removed by evaporation to give crude 2'-(2-bromoacetyl)-4',5'-dimethoxy-N-methylformanilide.

Provenance & Evidence