Potassium Hydroxide → HCID 178526269, compound

HRID 358714Notes

Reaction equation

HRID 358714 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][C:13]([F:16])([F:15])[F:14])=[CH:9][CH:10]=2)[N+:5]([O-:17])=[CH:4][CH:3]=1.[OH-:18].[K+]>>[OH:18][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][C:13]([F:16])([F:15])[F:14])=[CH:9][CH:10]=2)[N+:5]([O-:17])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 23128124HCID 23128124, compound

Product 1

HCID 178526269HCID 178526269, compound

Procedure

4-Chloro-7-trifluoromethoxyquinoline-1-oxide (9.4 g) and potassium hydroxide (20.0 g) were dissolved in industrial methylated spirit (320 ml) and the solution was heated under reflux for 90 minutes. The solvent was removed by evaporation and the residue dissolved in water (100 ml). Glacial acetic acid (40 ml) was added at 0 to 5°, the precipitate collected, washed with water (2×10 ml) and crystallised from methanol (120 ml) to give the novel compound 4-hydroxy-7-trifluoromethoxyquinoline-1-oxide, m.p. 80°-181°.

Workup

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 90 minutes
  3. customThe solvent was removed by evaporation
  4. dissolutionthe residue dissolved in water (100 ml)
  5. additionGlacial acetic acid (40 ml) was added at 0 to 5°
  6. customthe precipitate collected
  7. washwashed with water (2×10 ml)
  8. customcrystallised from methanol (120 ml)

Sources & evidence

ORD record
ord-b4bc9462cf954862af26df61a6753a42
Source dataset
uspto-grants-1991_03
Patent number
US04997840

Reaction notes

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