Potassium Hydroxide → HCID 178526266, compound

HRID 358717Notes

Reaction equation

HRID 358717 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:9][CH:10]=2)[N+:5]([O-:18])=[CH:4][CH:3]=1.[OH-:19].[K+]>>[OH:19][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:9][CH:10]=2)[N+:5]([O-:18])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 23128090HCID 23128090, compound

Product 1

HCID 178526266HCID 178526266, compound

Procedure

A solution of 4-chloro-7-phenylquinoline-1-oxide (1.9 g) and potassium hydroxide (4.2 g) in industrial methylated spirit (70 ml) was heated under reflux for 3 hours. The solvent was removed by distillation and water (200 ml) was added. The mixture was filtered and the filtrate neutralised with glacial acetic acid (5 ml). The precipitate was collected by filtration and purified by crystallisation from industrial methylated spirit (100 ml) to give the novel compound '4-hydroxy-7-phenylquinoline-1-oxide, m.p. 244°-250° decomp.

Workup

  1. temperatureunder reflux for 3 hours
  2. customThe solvent was removed by distillation and water (200 ml)
  3. additionwas added
  4. filtrationThe mixture was filtered
  5. filtrationThe precipitate was collected by filtration
  6. custompurified by crystallisation from industrial methylated spirit (100 ml)

Sources & evidence

ORD record
ord-907928dbb3e5430e96371e55a4120555
Source dataset
uspto-grants-1991_03
Patent number
US04997840

Reaction notes

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