Formic Acid → HCID 86744651, compound

Participants

Reaction Steps

2-Chloro-5'-methoxy-4'-methyl-2'-(methylamino)acetophenone (10 g) is added at ambient temperature to a stirred mixture of acetic anhydride (23 ml) and formic acid (16 ml), previously stirred at 55° for a 1hour, and the resultant mixture is stirred for 2 hours at 20°. Water (80 ml) followed by aqueous sodium hydroxide (specific gravity 1.5, 60 ml) are added, whilst maintaining the temperature below 10°. The mixture is then extracted with dichloromethane to give a solution of 2'-(2-chloroacetyl)-4'-methoxy-5'-methyl-N-methylformanilide.

Provenance & Evidence