Acetyl chloride → HCID 67903829, compound

HRID 358729Notes

Reaction equation

[CH2:1]([O:17][CH2:18][C@@H:19]1[CH2:23][O:22][C@@H:21]([CH2:24][O:25][C:26]([NH:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)=[O:27])[CH2:20]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].C(Cl)(=O)C.[Br:40][CH2:41][C:42](Cl)=[O:43]>>[Br:40][CH2:41][C:42]([N:28]([CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=1)[C:26]([O:25][CH2:24][C@H:21]1[CH2:20][C@H:19]([CH2:18][O:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH2:23][O:22]1)=[O:27])=[O:43]

Participants

Reactant 3

HCID 6367Acetyl chloride

HCID 89602Bromoacetyl chloride

HCID 67903441HCID 67903441, compound

Product 1

HCID 67903829HCID 67903829, compound

Procedure

Following the procedure described in example 24, and using instead of the compound prepared in example 23, the compound prepared in example 9, and instead of acetyl chloride, bromoacetyl chloride, the title compound of this example was obtained as a white solid (57% yield).

Sources & evidence

ORD record: ord-198ee944a04f4064b7c8d03698491c77
Source dataset: uspto-grants-1991_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04997843

Reaction notes

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