2-Phenylbutyric Acid → Methyl 3-methoxy-4-[2,3,5-trimethyl-6-(2-phenylbutanamido)indol-1-ylmethyl]-benzoate

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Reaction Steps

Similarly, starting from methyl 4-(6-amino-2,3,5-trimethylindol-1-ylmethyl)-3-methoxybenzoate (itself obtained using the procedures described for A in Example 1 but starting from 2,3,5-trimethyl-6-nitroindole [G]) and 2-phenylbutyric acid, there was obtained methyl 3-methoxy-4-[2,3,5-trimethyl-6-(2-phenylbutanamido)indol-1-ylmethyl]benzoate [Example 83] in 32% yield as a white solid; partial NMR: 0.9 (t,3H,CH2CH3), 1.2 (m,2H, CH2CH3), 3.4 (t,1H,CHPh), 7.3 (s,5H,Ph).

Provenance & Evidence