Potassium Carbonate → 1-(4-Cyano-2-methoxybenzyl)-6-nitroindole

Participants

Reaction Steps

6-Nitroindole was alkylated with 4-bromomethyl-3-methoxybenzonitrile in the presence of potassium carbonate using the general procedure described in Ex 1(a) to give 1-(4-cyano-2-methoxybenzyl)-6-nitroindole (W) in 78% yield as a solid, m.p. 190.5°-191° C. (b) The nitrile W was converted to the corresponding tetrazole, 1-(2-methoxy-4-[1-(H)-tetrazol-5-yl]benzyl)6-nitroindole (X), obtained in 86% yield as a yellow-green solid, m.p. 258°-260° C. (d) using the general procedure of Example 67.

Provenance & Evidence