Cyclopentylacetyl chloride → N-(4-[6-(2-cyclopentylacetamido)indol-1-ylmethyl]-3-methoxybenzoyl)benzenesulphonamide

HRID 358747Notes

Reaction equation

[CH:1]1([CH2:6][C:7](Cl)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:10][C:11]1[CH:19]=[C:18]2[C:14]([CH:15]=[CH:16][N:17]2[CH2:20][C:21]2[CH:38]=[CH:37][C:24]([C:25]([NH:27][S:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)(=[O:30])=[O:29])=[O:26])=[CH:23][C:22]=2[O:39][CH3:40])=[CH:13][CH:12]=1>>[CH:1]1([CH2:6][C:7]([NH:10][C:11]2[CH:19]=[C:18]3[C:14]([CH:15]=[CH:16][N:17]3[CH2:20][C:21]3[CH:38]=[CH:37][C:24]([C:25]([NH:27][S:28]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)(=[O:30])=[O:29])=[O:26])=[CH:23][C:22]=3[O:39][CH3:40])=[CH:13][CH:12]=2)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 3485182Cyclopentylacetyl chloride

HCID 19744290HCID 19744290, compound

Product 1

HCID 14753021N-(4-[6-(2-cyclopentylacetamido)indol-1-ylmethyl]-3-methoxybenzoyl)benzenesulphonamide

Procedure

Using a similar procedure to that described in Example 157, but starting with 2-cyclopentylacetyl chloride and N-(4-[6-aminoindol-1-ylmethyl]-3-methoxybenzoyl)benzenesulphonamide, there may be obtained N-(4-[6-(2-cyclopentylacetamido)indol-1-ylmethyl]-3-methoxybenzoyl)benzenesulphonamide as a solid essentially identical in physical properties to that obtained in Example 280.

Sources & evidence

ORD record: ord-060dc8e41f3f4b09ba576a39d6f97ee3
Source dataset: uspto-grants-1991_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04997844

Reaction notes

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