反应详情

A mixture of 306 mg. 4-[6-(cyclopentyloxycarbonyl)aminoindazol-1-ylmethyl]-3-methoxybenzoic acid in 4 ml. methanol and 6 ml. methylene chloride was treated with 0.75 ml. of 1 M sodium hydroxide solution. After 15 minutes the mixture was evaporated and the residue was recrystallised from ether/methylene chloride/methanol to give sodium 4-[6-(cyclopentyloxycarbonyl)aminoindazol-1-ylmethyl]-3-methoxybenzoate in 78% yield as a solid, m.p. >280° C. (d); microanalysis, found: C,59.80; H,5.06; N,9.20%; C22H22H3O5Na.0.5H2O requires C, 59.99; H,5.26; N,9.54%.

1. additionA mixture of 306 mg
2. customAfter 15 minutes the mixture was evaporated
3. customthe residue was recrystallised from ether/methylene chloride/methanol