2-(3-Bromopropoxy)tetrahydro-2H-pyran → HCID 19744350, compound

HRID 358752Notes

Reaction equation

HRID 358752 reaction equation
[C:1]([NH:8][C:9]1[CH:17]=[C:16]2[C:12]([CH:13]=[CH:14][NH:15]2)=[CH:11][CH:10]=1)(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].Br[CH2:19][CH2:20][CH2:21][O:22][CH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][O:24]1>>[C:1]([NH:8][C:9]1[CH:17]=[C:16]2[C:12]([CH:13]=[CH:14][N:15]2[CH2:19][CH2:20][CH2:21][O:22][CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][O:24]2)=[CH:11][CH:10]=1)(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

3

Reactant 2

HCID 27779882-(3-Bromopropoxy)tetrahydro-2H-pyranHCID 14752993HCID 14752993, compound

Product 1

HCID 19744350HCID 19744350, compoundYield 81%

Procedure

6-Hexanamidoindole was alkylated with 2-(3-bromopropoxy)tetrahyro-2H-pyran using a similar procedure to that described in Example 23 to give 2-[3-(6-hexanamidoindol-1-yl)propoxy]tetrahydro-2H-pyran in 81% yield as an oil, which was used without characterisation.

Sources & evidence

ORD record
ord-3e8634bc263842d09bb7003e6f7e9d12
Source dataset
uspto-grants-1991_03
Patent number
US04997844

Reaction notes

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