Methanol → HCID 10341501, compound

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Reaction Steps

Methanol (6 ml) is added dropwise taking 30 minutes under reflux by heating, while stirring, to a mixture of methyl 1-tert-butoxycarbonyl-4-(3,4,5-trimethoxybenzoyl)piperazine-2-carboxylate (6.3 g), sodium borohydride (1.64 g) and tetrahydrofuran (80 ml). The reaction mixture is poured into water, followed by extraction with ethyl acetate. The organic layer is washed with water and dried, then the solvent is distilled off. Crystals obtained from the residue are recrystallized from ethyl acetate-ether to afford 1-tert-butoxycarbonyl-4-(3,4,5-trimethoxybenzoyl)piperazine-2-methanol (4.15 g) as colorless crystals, m.p. 119-120° C.

Provenance & Evidence