HCID 20066633, compound → HCID 20066665, compound

Participants

Reaction Steps

A mixture of N,N-dimethyl 1-tert-butoxycarbonyl-4(3,4,5-trimethoxybenzoyl)piperazine-2-carboxamide (2.0 g) and 3N HCl - ethyl acetate (20 ml) is stirred for 30 minutes at room temperature. The reaction mixture is concentrated, and the concentrate is poured into a saturated aqueous solution of potassium carbonate, followed by extraction with dichloromethane. The organic layer is dried and concentrated to afford N,N-dimethyl 4-(3,4,5-trimethoxybenzoyl)piperazine-2-carboxamide (1.5 g) as colorless crystals, m.p. 167-168° C.

Provenance & Evidence