Toluene → HCID 86744655, compound

Participants

Reaction Steps

To a mixture of ethyl 4-(3,4,5-trimethoxybenzoyl)2-piperazine propionate hydrochloride obtained in Reference Example 31 (1.3 g), triethylamine (315 mg) and toluene (10 ml) is added dropwise, while stirring, at room temperature a 3.4M toluene solution of sodium bis(2-methoxyethoxy)aluminum hydride (Red-Al®) (9 g). To the reaction mixture, after stirring for 3 hours, is added water, followed by extraction with ethyl acetate. The organic layer is washed with water, dried and concentrated under reduced pressure. The concentrate is led to its hydrochloride, which is recrystallized from ethanol to give 4-(3,4,5-trimethoxybenzyl)-2piperazine propanol dihydrochloride as colorless crystals (1 0 g) m.p. 212-215° C.

Provenance & Evidence