Sodium Hydroxide → HCID 14071844, compound

Participants

Reaction Steps

130 mg (0.0003 mole) of 1-ethyl-6-fluoro-8-methoxy-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid boron trifluoride addition product (prepared as described in Example 39) were dissolved in 30 ml of water. 0.36 ml of a 1N aqueous solution of sodium hydroxide was added to the solution, and the reaction mixture was concentrated by evaporation under reduced pressure to give crystals. These were recrystallized from ethanol and then washed with cold water, to give 70 mg of 1-ethyl-6-fluoro-8-methoxy-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid as a pale brown powder melting at 207°-209° C. (with decomposition).

Provenance & Evidence