HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2,4,5-Trifluoro-3-methoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2,4,5-Trifluoro-3-methoxybenzoic acid | HCID 2733970 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 2,4,5-Trifluoro-3-methoxybenzoyl chloride | HCID 2775281 | — |
Reaction Steps
To a solution of 1.14 g (0.0055 mole) of 3-methoxy-2,4,5-trifluorobenzoic acid (XXVI) (prepared as described in Preparation 1 or 2) in 10 ml of dry benzene was added 5 ml of thionyl chloride and the mixture was heated under reflux for 1 hour. At the end of this time, benzene and the excess of thionyl chloride were removed completely to give 3-methoxy-2,4,5-trifluorobenzoyl chloride (XXVII) [Step (E7)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04997943 |
| Source dataset | uspto-grants-1991_03 |
| ORD ID | ord-e8340abe867a4d70b81c6228fb698fd8 |
| Source note | uspto-grants-1991_03 |