反应详情

A mixture of 2-[(4-bromobutyl)oxy]naphthalene (5.5 g), sodium acetate (13.1 g), trioctylpropylammonium chloride (1.21 g) and water (19 ml) was stirred at ca 100° for 2 h. 2N sodium hydroxide solution (32 ml) and ethanol (32 ml) were added to the cooled mixture which was stirred for a further 10 min at room temperature. The ethanol was evaporated in vacuo and the residue diluted with brine (150 ml) and extracted with ether (2×100 ml), which was dried and evaporated in vacuo to give a white solid. The solid was dissolved in ether and purified by FCC eluting with hexane-ether (2:1→1:2) to give the title compound as a white solid (1.36 g), m.p. 66.5°-67.5°.

1. stirringwas stirred for a further 10 min at room temperature
2. customThe ethanol was evaporated in vacuo
3. additionthe residue diluted with brine (150 ml)
4. extractionextracted with ether (2×100 ml), which
5. customwas dried
6. customevaporated in vacuo
7. customto give a white solid
8. custompurified by FCC
9. washeluting with hexane-ether (2:1→1:2)