Zinc → Zn N-benzenesulfonylpiperidine-4-carboxylate

HRID 358938Notes

Reaction equation

HRID 358938 reaction equation
[C:1]1([S:7]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([OH:18])=[O:17])[CH2:12][CH2:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Zn:19]>O.[OH-].[Na+]>[Zn:19].[C:1]1([S:7]([N:10]2[CH2:11][CH2:12][CH:13]([C:16]([O-:18])=[O:17])[CH2:14][CH2:15]2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 23994ZincHCID 7377181-(Benzenesulfonyl)piperidine-4-carboxylic acid

Product 1

HCID 86744659Zn N-benzenesulfonylpiperidine-4-carboxylate

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
50 °C

Procedure

12.12 g (0.045M) of N-benzenesulfonylpiperidine-4-carboxylic acid were dissolved in 250 ml of water with the addition of 22.5 ml of 4N NaOH at 50° C. Thereafter, 2.94 g (0.045M) of ZnSO4.7H2O, dissolved in 100 ml of water, was slowly added at 50° C. After the mixture had been stirred for 3 1/2 hours at 50° C., the resulting pH was 7.3. The mixture was then stirred at room temperature, and the product was filtered off under suction, washed and dried. 15.8 g of a product which contained 1.05 moles of Zn per mole of starting acid resulted.

Workup

  1. additionwas slowly added at 50° C
  2. stirringThe mixture was then stirred at room temperature
  3. filtrationthe product was filtered off under suction
  4. washwashed
  5. customdried
  6. customresulted

Sources & evidence

ORD record
ord-c224ce8d77f04898a8f045b42a8358c8
Source dataset
uspto-grants-1991_03
Patent number
US04999134

Reaction notes

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