Methylamine → HCID 20065686, compound

Participants

Reaction Steps

9 g (34.22 mmoles) of 1-(3-pyridinyl)-2-(1-pyrrolidinyl) ethanone dihydrochloride were suspended in 110 ml of tetrahydrofuran containing 20% of monomethylamine. After 15 mins. of stirring, 3.6 g (57.32 mmoles) of sodium cyanoborohydride were added at room temperature. After 24 h the reaction mixture was evaporated in vacuo to dryness. The residue was taken up with conc. NaOH solution and exhaustively extracted with diethyl ether. The organic solution was dried and evaporated in vacuo to dryness. 4.2 g of the crude product were obtained and used, without further purification, in the following step.

Provenance & Evidence