Chloroform → HCID 20065684, compound

HRID 358966Notes

Reaction equation

HRID 358966 reaction equation
[N:1]1([CH2:6][CH:7]2[C:12]3[CH:13]=[CH:14][S:15][C:11]=3[CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:16]1[C:24]2[C:19](=[CH:20][C:21]([CH2:25][C:26](O)=[O:27])=[CH:22][CH:23]=2)[CH2:18][CH2:17]1.C1(N=C=NC2CCCCC2)CCCCC1.C(Cl)(Cl)[Cl:45]>>[ClH:45].[N:1]1([CH2:6][CH:7]2[C:12]3[CH:13]=[CH:14][S:15][C:11]=3[CH2:10][CH2:9][N:8]2[C:26](=[O:27])[CH2:25][C:21]2[CH:20]=[C:19]3[C:24](=[CH:23][CH:22]=2)[CH2:16][CH2:17][CH2:18]3)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 4

HCID 6212ChloroformHCID 10868DicyclohexylcarbodiimideHCID 2273612,3-dihydro-1h-inden-5-ylacetic acidHCID 15697345HCID 15697345, compound

Product 1

HCID 20065684HCID 20065684, compound

Procedure

Prepared as Example No. 3, from 1.5 g (6.76 mmoles) of 4-(pyrrolidin-1-yl)methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine, 1.4 g (7.95 mmoles) of indan-5-yl acetic acid and 2.4 g (11.76 mmoles) of dicyclohexylcarbodiimide in 50 ml of dry chloroform.

Sources & evidence

ORD record
ord-43dd2605fa654fc29bb5c6e3e3352939
Source dataset
uspto-grants-1991_03
Patent number
US04999359

Reaction notes

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