反应详情

A solution of 6 ml of chloroform and of 6,8 ml of methyl ethyl ketone is added dropwise in about 30 minutes to a suspension of 5.9 g of 1-benzyl-3-hydroxymethyl-indazole, prepared as described above, of 12 g of NaOH and of 35 ml of methyl ethyl ketone. When the addition is over, the reaction mixture is heated to reflux. After 60 minutes, the reaction mixture is cooled, water is added and the aqueous phase is separated and acidified. The resulting oil is extracted with diethyl ether and the solvent is evaporated to give an oil that hardens and is crystallized from hexane/ethyl acetate 1:1; the ether of 1-benzyl-3-hydroxymethyl-indazole with 2-hydroxy-2-ethyl-propionic acid is thus obtained (Compound I, R=CH3, R'=C2H5, R"'=H), m.p. 115°-116° C.

1. customprepared
2. additionWhen the addition
3. temperatureis heated to reflux
4. temperaturethe reaction mixture is cooled
5. customthe aqueous phase is separated
6. extractionThe resulting oil is extracted with diethyl ether
7. customthe solvent is evaporated
8. customto give an oil that hardens
9. customis crystallized from hexane/ethyl acetate 1:1