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HRID358992

反应详情

EQUATION

反应方程式

HRID 358992 的结构方程式

REACTANTS

反应物

2
结构：C=CC#N
HCID7855

Acrylonitrile

C3H3N

结构：CCOC(=O)C1=C(C)NC(CS)=C(C(=O)OCC)C1c1cccc([N+](=O)[O-])c1
HCID11675833

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)C1=C(C)NC(CSCCC#N)=C(C(=O)OCC)C1c1cccc([N+](=O)[O-])c1
HCID19831203

未命名化合物

收率 92%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)C(=N)N(C)C
催化剂HCID66460

Guanidine, N,N,N',N'-tetramethyl-

C5H13N3

结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A solution of 2-mercaptomethyl-3,5-dicarboethoxy-4-(m-nitrophenyl)-6-methyl-1, 4-dihydropyridine (5 g), acrylonitrile (0.66 g) and 1,1,3,3-tetramethylguanidine (0.1 g) in EtOH (60 ml) is stirred at room temperature for 18 hours and then evaporated to dryness. After the usual work-up, the residue is recrystallized from Et2O to give 5.2 g of 2-[(2-cyanoethyl)thio]methyl-3,5-dicarboethoxy-4-(m-nitrophenyl) -6-methyl-1,4-dihydropyridine m.p. 102°-104° C.

WORKUP

后处理

  1. customevaporated to dryness
  2. customAfter the usual work-up, the residue is recrystallized from Et2O