HCID 20066008, compound → HCID 67826849, compound

Participants

Reaction Steps

Methyl 4-[2-(2-hydroxy-3-phenoxypropylamino)ethyl]-phenoxyacetate hydrochloride (3.0 g) was suspended in 2N hydrochloric acid (150 ml) and heated on the steam bath for 2 hours. A clear solution was produced, from which the product crystallised on cooling. The crystals were filtered off, washed with a small volume of 2N hydrochloric acid followed by ether, and dried over phosphorus pentoxide. Thus was obtained 4-[2-(2-hydroxy-3-phenoxypropylamino)-ethyl]phenoxyacetic acid hydrochloride (2.04 g) mp 192°-94° C.; NMR 2.86-3.33[m,6H, CH2NHCH2CH2 ]: 4.02[m,2H, PhOCH2 ]; 4.22[m,1H,CHOH]; 4.63[s,2H, OCH2CO]; 6.84-7.38[m,9H, aromatic H]: microanalysis: found C, 59.8; H, 6.3; N, 3.5; Cl, 9.3%; C19H23NO5.HCl requires: C, 59.8; H, 6.3; N,3.7; Cl, 9.3 %.

Provenance & Evidence