Hydrochloric Acid → HCID 20066008, compound

Participants

Reaction Steps

The starting material was prepared by dissolving methyl 4-[2-(N-benzyl-N-(2-hydroxy-3-phenoxypropyl)amino)ethyl]phenoxyacetate (3.0 g) (see Example 8) in methanol (150 ml), adding ethereal hydrogen chloride dropwise to give a pH of 3, followed by 10% palladium on carbon (250 mg). The mixture was stirred under an atmosphere of hydrogen for 16 hours. The catalyst was removed by filtration through diatomaceous earth and the filtrate evaporated to give methyl 4-[2-(2-hydroxy-3-phenoxypropylamino)ethyl]phenoxyacetate hydrochloride (3.0 g) in the form of a gum, which was used directly and without further purification

Provenance & Evidence