反应详情

温度

70 °C

Methyl 4-(2,2-diethoxyethoxy)benzoate (36.29 g) was dissolved in dioxane (100 ml), added thereto 2N sulfuric acid (200 ml), and the mixture was heated with stirring at 70° C. for 6 hours. After concentrated under reduced pressure to about half volume, it was diluted with water in two fold, and concentrated again under reduced pressure. The precipitate was collected by filtration, and washed successively with aqueous sodium hydrogencarbonate solution and water to give methyl 4-formylmethoxybenzoate (24.39 g). mp. 58°-60° C.

1. additionadded
2. concentrationAfter concentrated under reduced pressure to about half volume, it
3. additionwas diluted with water in two fold
4. concentrationconcentrated again under reduced pressure
5. filtrationThe precipitate was collected by filtration
6. washwashed successively with aqueous sodium hydrogencarbonate solution and water