反应详情

温度

60 °C

Methyl 4-[3-[N-(3,4-methylenedioxyphenyl)amino]propoxy]benzoate (1.5 g) was suspended in methanol (20 ml), and thereto a solution of sodium hydroxide (0.55 g) in water (5 ml) was added, then, the mixture was heated with stirring at 60° C. for 13 hours. After the reaction solution was concentrated under reduced pressure, the residue was washed with ether several times, and further thereto were added water and a neutralization amount of conc. hydrochloric acid. The resulting crystal was collected by filtration to give the desired product (0.99 g). mp. 164°-167° C. (decomposed).

1. temperaturethe mixture was heated
2. concentrationAfter the reaction solution was concentrated under reduced pressure
3. washthe residue was washed with ether several times
4. additionfurther thereto were added water
5. filtrationThe resulting crystal was collected by filtration