Hydrochloric Acid → HCID 14882834, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4-[3-[N-(4-tert-butylphenyl) -N-(3,4methylenedioxybenzoyl)amino]propoxy]benzoate (2.0 g) was dissolved in methanol (40 ml) and thereto was added a solution of sodium hydroxide (0.33 g) in water (10 ml), the mixture was heated with stirring at 60° C. for 23 hours. The reaction solution was cooled, and the solution was adjusted to pH 4-5 with conc. hydrochloric acid. The mixture was diluted with water and the precipitate was collected by filtration and washed with water. The precipitate was recrystallized from ethyl acetate/hexane to give the desired product (1.57 g). mp. 199°-203° C.

Provenance & Evidence