Hydrochloric Acid → HCID 14882840, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4-[3-[N-(4-chlorophenyl)-N-ethylamino]propoxy]benzoate (1.37 g) was dissolved in methanol (20 ml), and a solution of sodium hydroxide (0.48 ml) in water (5 ml) was added thereto, the mixture was heated with stirring at 60° C. for 13 hours. The reaction mixture was cooled, and was added a neutralization amount of conc. hydrochloric acid thereto, then the mixture was concentrated under reduced pressure. The residue was suspended in water, and collected by filtration, and washed with water to give the desired product (1.20 g). mp. 146°-149° C.

Provenance & Evidence