Hydrochloric Acid → HCID 14882845, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4-[3-[N-acetyl-N-(4-chlorophenyl)amino]propoxy]benzoate (1.20 g) was dissolved in methanol (20 ml), and 1N aqueous sodium hydroxide solution (4.99 ml) was added thereto, the mixture was heated with stirring at 60° C. for 27 hours. The reaction mixture was cooled, and the mixture was adjusted to pH 4-5 by adding conc. hydrochloric acid. The mixture was concentrated under reduced pressure and thereto was added water. The precipitate was collected by filtration, and washed with water to give the desired product (1.09 g). mp. 169°-171° C.

Provenance & Evidence