Acrylic Acid → HCID 15086626, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4-[3-[N-[4-chlorophenyl)amino]propoxy]benzoate (2.0 g) was dissolved in toluene (6 ml), and thereto was added acrylic acid (2.24 ml), and the mixture was heated with stirring at 100° C. for 24 hours. The reaction mixture was diluted with ethyl acetate, and washed successively with aqueous sodium bicarbonate solution 2 times and water once, and it was concentrated under reduced pressure. The residue was subjected to column chromatography on silica gel and eluted with a mixed solvent of chloroform/methanol [60:1 (v/v)] to give the oily desired product (1.64 g).

Provenance & Evidence