Hydrochloric Acid → HCID 14882889, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4-[3-[N-(2-carboxyethyl)-N-(4-chlorophenyl)amino]propoxy]benzoate (1.37 g) was dissolved in methanol (20 ml) and thereto was added a solution of sodium hyroxide (0.42 g) in water (4 ml), and the mixture was heated with stirring at 60° C. for 23 hours. After the reaction mixture was cooled, a neutralizing amount of conc. hydrochloric acid was added thereto, then, concentrated under reduced pressure. The residue was allowed to stand in water (pH; about 4.5) and the resulting crystal was collected by filtration, washed with water, and recrystallized from about 30 % aqueous methanol to give the desired product (0.87 g). mp. 132°-133° C.

Provenance & Evidence