Hydrochloric Acid → HCID 14882891, compound

Participants

Reaction Steps

Methyl 4-[3-[N-carbamoyl-N-(4-chlorophenyl)amino]propoxy]benzoate (1.5 g) was dissolved in dioxane (30 ml), and thereto was added a solution of sodium hydroxide (0.33 g) in water (6 ml), and the mixture was stirred at room temperature for 22 hours. The reaction mixture was neutralized with conc. hydrochloric acid (0.7 ml), and the mixrure was concentrated under reduced pressure. The residue was crushed in aqueous methanol, and collected by filtration to give the desired product (1.27 g). mp. 172°-174° C.

Provenance & Evidence