Hydrochloric Acid → HCID 14882899, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4-[2-[N-(4-chlorophenyl)amino]cyclopentan-1-ylmethoxy]benzoate (2.57 g) was dissolved in methanol (40 ml) and thereto was added a solution of sodium hydroxide (0.86 g) in water (8 ml), and the mixture was heated with stirring at 60° C. for 14 hours. The reaction mixture was cooled and thereto was added conc. hydrochloric acid (1.87 ml), then, the mixture was concentrated under reduced pressure. The residue was washed with water and about 50 % aqueous methanol was added thereto, and the mixture was heated. The mixture was allowed to stand, and the resulting crystal was collected by filtration to give the desired product (1.72 g). mp. 153°-156° C.

Provenance & Evidence