Methanol → HCID 20066103, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[(3-hydroxy-2,2-dimethylpropyl)amino]anthraquinone (88.0 g, 0.28 mol) in pyridine (400 mL) is added bromine (48.0 g, 0.30 mol) with vigorous agitation, allowing the temperature to rise to about 40° C. The reaction is completed by heating at 90 to 95° C. for 6 hours and then allowed to cool. Methanol (200 mL) is added, stirring continued for about 2 hours at room temperature and the product is then drowned into water with thorough stirring. The solids are collected by filtration, washed with water and dried in air to give 101.3 g of 4-bromo-l-[(3-hydroxy-2,2-dimethyl-propyl) amino]anthraquinone. The identity of the product is confirmed by mass spectrometry analysis.

Provenance & Evidence