反应详情

A mixture of 4.3 g of 3-methyl-2-buten-1-ol, 16.2 g of ethyl orthoacetate and 86 mg of boric acid was heated for 2 hours at 120° with stirring, during which ethanol was evolved and removed. The temperature was then increased to 145°-150° where it was maintained for an additional 8 hours. When ethanol evolution ceased, the mixture was distilled to separate unreacted ethyl orthoacetate from 6.25 g (80% yield) of ethyl 3,3-dimethyl-4-pentenoate, b.p. 78°-80°/51 mm.

1. temperaturewas heated for 2 hours at 120°
2. customremoved
3. temperatureThe temperature was then increased to 145°-150° where it
4. temperaturewas maintained for an additional 8 hours
5. distillationthe mixture was distilled